Many southern European regions suffer from high youth unemployment, including among university graduates, and severe constraints on public funding. In this context, higher education institutions are increasingly being judged on how they respond to the social and economic needs of society, on their actions to increase the employability of graduates, on their contribution to national economic growth and local development, and on how they stimulate the creation of new businesses and innovation in existing businesses. In line with evidence from European research, HEIs can respond to these challenges by fostering students' entrepreneurial mindset and transversal key skills such as foreign language skills in order to increase the employability of their students and contribute to economic growth. Higher education institutions in Southern Europe need innovative low-cost methodologies and educational models to improve the effectiveness of entrepreneurship education in terms of acquiring and developing skills that can be easily adapted, replicated and extended according to their specific needs and circumstances.